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Orforglipron FDA Approval: Why the First Small-Molecule GLP-1 Pill Matters
These include direct effects on GLP-1R + cells within joints, the heart, kidney, liver, and immune cells 14 and indirect actions through weight reduction and blood glucose control, as well as through interorgan communication to dampen inflammation via activation of GLP-1R in subsets of central nervous system neurons 15 (Figure 1B)
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References: Bliddal H, et al
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