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Endothelial GLP-1R has been shown to be involved in endothelial dysfunction in a mouse angiotensin II-induced hypertension model (Helmstadter et al., 2020)
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Specifically, insulin dysregulation has two distinct dimensions: (1) the first dimension of pathophysiology of hyperinsulinism which predates Type 2 diabetes (T2D) and is not accompanied by glycemic abnormalities detectable by the laboratory tests in current use
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