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The math: Baseline NAION incidence in people with diabetes: approximately 6.7 per 100,000 patient-years (from the Hathaway control group) Incidence in GLP-1 users: approximately 17 to 20 per 100,000 patient-years Absolute risk increase: 10 to 13 additional cases per 100,000 patient-years Number needed to harm (NNH): approximately 7,700 to 10,000 patient-years This means if 10,000 patients take a GLP-1 medication for one year, roughly 1 to 2 additional NAION cases will occur compared to if those patients took a non-GLP-1 medication
