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A pivotal shift occurred on December 1, 2025, when the World Health Organization (WHO) released its first-ever clinical guidelines recommending GLP-1 receptor agonists for the long-term treatment of obesity
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In the latter half of the 20th century, Dow chemist Alexander Shulgin, famous for popularizing MDMA and a range of other potent psychedelic analogues, held gatherings at his home, sampling his latest creations with a group of like-minded fellow travelers