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This matters for fat loss because chronic inflammation is now understood to be a driver of insulin resistance, which in turn makes losing body fat significantly harder
![12-Month Weight Loss and Adherence in a Real-World Tirzepatide-Supported Digital Obesity Service[v1]](https://www.preprints.org/frontend/picture/ms_xml/manuscript/c5bf8e42e66fb00fd0dbbf0771fe2da2/preprints-187058-g002.png)
