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However, both preclinical 17–20 and clinical 21,22 studies largely agree that GIP and GLP-1 are the two primary physiological incretins that mediate nutrient signaling from the intestine to the pancreatic islets, to properly regulate insulin secretion in control of postprandial glucose metabolism
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18 Developed over 10 years and with $25M of government-backed research, it’s also been shown to reduce overall hunger during a 24-hour fast by 25% and 30% in men and women, respectively
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