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Taken together, these observations suggest that a reduction in the deceleration of gastric emptying may occur even within 4 hours of administration of exogenous GLP-1RAs (20)

Chemical Analog

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Abbreviations ACEI angiotensin-converting enzyme inhibitors AHAs anti-hyperglycemic agents Ang II angiotensin II ARBs angiotensin receptor blockers BP blood pressure BUN blood urea nitrogen CI confidence interval CV cardiovascular DKD diabetic kidney disease DPP-4 dipeptidyl peptidase-4 eGFR estimated glomerular filtration rate EGP endogenous glucose production FPG fasting plasma glucose GFR glomerular filtration rate GLP-1 glucagon-like peptide-1 GLP1-RAs glucagon-like peptide-1 receptor agonists HbA1c glycated haemoglobin HDL-C high density lipoprotein-cholesterol HF heart failure HGP hepatic glucose production LDL-C low density lipoprotein-cholesterol MACE major adverse cardiovascular events MRAs mineralocorticoid receptor antagonists NF-kB nuclear factor kappa B OLETF Otsuka Long-Evans Tokushima Fatty PK-PD pharmokinetics and pharmacodynamic RAAS renin–angiotensin–aldosterone system RAS renin–angiotensin system RCT randomized controlled trial SBP systolic blood pressure SGLT2 sodium–glucose co-transporter 2 STZ streptozocin T2DM type 2 diabetes mellitus UACR urine albumin–creatinine ratio UGE urinary glucose excretion Footnotes Honghong Zou and Baoqin Zhou contributed equally to this work Contributor Information Honghong Zou, Email: [email protected]