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A provider who prescribes without setting realistic expectations sets the patient up for perceived treatment failure and discontinuation
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α-integrins bind β-integrins to form obligate heterodimers that, upon ligand binding, usually trigger canonical signaling via phosphorylation of focal adhesion kinase (FAK), AKT/protein kinase B (PKB), and cAMP response element-binding protein (CREB) [21,22]
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