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This mismatch between intended pharmacokinetics and actual absorption can lead to stronger initial effects, unpredictable appetite suppression timing, and potentially more pronounced side effects in the first hours or days after injection
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12 As this confers a much longer half-life than that of native sequence GLP-1 (hours rather than minutes), the development of GLP-1 RAs has proceeded down two paths: as analogues of either human GLP-1, or of exendin-4
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