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GLP-1RAs, such as lixisenatide, not only rely on β-cell function and glucagon suppression, but also assist to lower glucose by other (insulin-independent) mechanisms such as delayed gastric emptying, underlying the clinical utility of GLP-1RAs as adjuvant therapy to basal insulin in longstanding T2DM [14]
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When considering 2028, “people are scratching their heads, saying: ‘What will I do then?’” In the meantime, physicians such as Moore and Weber hope the program will allow more patients to start taking a GLP-1
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