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In general, clinical blood pressure figures 60ml/min, but half doses should be used if the GFR is 60ml/min/1.73m2), especially if they have microalbuminuria, since the strict control of glycaemia in these cases may delay the progression of the renal lesion.61 By contrast, in patients with long-term T2DM, with major comorbidities, a marked risk in episodes of hypoglycaemia, a high vascular risk or a short life expectancy, a less intensive glycaemic control is recommended (HbA1c 7.5%-8%).62 These targets could be used in moderate-advanced CKD patients (GFR 60ml/min/1.73m2.75 After they are metabolised in the liver, gliclazide and glipizide generate inactive metabolites that are mostly eliminated through urine, and as such, there is less risk that they will cause severe hypoglycaemia
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