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While this finding has not been confirmed in humans during extensive clinical trials and post-marketing surveillance, the FDA requires a boxed warning on GLP-1 receptor agonist labels regarding this potential risk

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doi: 10.1055/s-0042-109065 Summary Keywords diabetes mellitus type 2, cardiovascular disease, cardiovascular risk, diabetic kidney disease, sodium-glucose cotransporter-2 inhibitor, glucagon-like peptide-1 receptor agonist, aldosterone, renin Citation Puglisi S, Rossini A, Poli R, Dughera F, Pia A, Terzolo M and Reimondo G (2021) Effects of SGLT2 Inhibitors and GLP-1 Receptor Agonists on Renin-Angiotensin-Aldosterone System