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The tirzepatide safety profile appears favorable compared to some other GLP-1 medications, though patients with personal or family history of medullary thyroid carcinoma should not use tirzepatide or any GLP-1/GIP agonist
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The SELECT trial tested semaglutide 2.4 mg in over 17,000 people with cardiovascular disease and obesity over an average of 3.3 years
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