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In this context, data obtained from experimental studies are often inconsistent when compared with those conducted on humans, and many aspects require deeper investigations (e.g., role of DPP-4 in different cell types, temporal and spatial characteristics of DPP-4 expression across different disease stages, identification of possible ligands for DPP-4, and approaches for targeting nonenzymatic DPP-4 activity) [46,80]

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With regard to nicotine use disorder, a randomized trial evaluating dulaglutide for smoking cessation found that abstinence rates at 12 weeks did not differ significantly between the dulaglutide and placebo groups (Lengsfeld et al., 2023)