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Gradual increase in foods with soluble and insoluble fiber, such as prunes or other dried fruits, can be helpful

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The effects were inhibited by coinfusion with exendin(9–39), a specific antagonist of the GLP-1R, indicating that active GLP-1 exerts its vascular protective effects through the classical GLP-1R, which is expressed in vascular smooth muscle cells and endothelial cells