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There is a suggestion from pooled data of increased rates of infections, specifically nasopharyngitis and urinary tract infections, which suggests a role for DPP-4 activity in normal immune surveillance, but whether this is clinically significant is still to be established

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Cinnamaldehyde is one of the most prominent natural TRPA1 agonists, capable of activating TRPA1 by covalent bonding to the channel’s cysteine-rich N-terminus [19,49]