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While ovarian cancers also show moderate elevation, GLP-1R expression remains relatively low in most other tissues, including adrenal gland, colon, liver, lung, and kidney, regardless of malignancy status [61]
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Limitations in metformin use include the risk of lactic acidosis with fluctuating kidney function, either with graft dysfunction or rejection in kidney transplantation or acute kidney injury in other solid organ transplantation
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