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Appendix Abbreviations ATP adenosine triphosphate BSEP/ABCB11 bile salt export pump Ca 2+ calcium ions cAMP cyclic adenosine monophosphate CCK cholecystokinin CYP7A1 cholesterol 7α-hydroxylase CYP8B1 sterol 12α-hydroxylase Epac2 exchange protein activated by cAMP-2 FGF19 fibroblast growth factor 19 FGFR4 fibroblast growth factor receptor 4 FXR farnesoid X receptor GLP-1 glucagon-like peptide-1 GLP-1R GLP-1 receptor GLP-1RAs glucagon-like peptide-1 receptor agonists HNF4α hepatocyte nuclear factor 4α IR insulin resistance MASLD metabolically associated steatotic liver disease NTS nucleus of the solitary tract PKA protein kinase A SHP small heterodimer partner T2DM type 2 diabetes mellitus TGR5 Takeda G-protein-coupled receptor 5 Footnotes ORCID iDs: Mohammed Eslam Nahum Méndez-Sánchez Contributor Information Mariana M