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While human relevance remains uncertain, tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

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[1] For patients with Hashimoto's thyroiditis, there is currently no evidence to suggest that Wegovy directly affects thyroid autoimmunity or accelerates the progression of autoimmune thyroid disease, though research specifically examining this relationship is limited