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Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events [23], decreased mortality in heart failure [[24], [25], [26], [27], [28]], and improvements in obstructive sleep apnea [12,29], prediabetes [30,31], chronic kidney disease [32], knee osteoarthritis [33], substance use disorders [34], and metabolic-associated steatotic liver disease [35]