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1 ACHIEVE-1 Trial Design and Objectives In the 40-week phase 3, randomized, double-blind, placebo-controlled ACHIEVE-1 trial, researchers compared the efficacy and safety of 3-mg, 12-mg, and 36-mg doses of orforglipron as a monotherapy compared with a placebo in individuals with T2D and inadequate glycemic control with diet and exercise alone

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