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In recent years, GIP/GLP-1 receptor dual agonists and GIP/GLP-1/glucagon receptor triple agonists, which co-stimulate multiple hormone receptors including GIPR, continue to be reported to exert remarkable anti-obesity and hypoglycaemic effects when compared to agonists of the GLP-1R alone, and are now being applied in clinical practice

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Although rodent studies consistently show thyroid C-cell tumors, human relevance remains uncertain due to marked species differences in GLP-1 receptor expression

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