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Moreover, although NADPH oxidases in hepatic stellate cells (NOX2 and NOX4) and macrophages (NOX2) contributed to the development of oxidative stress, the authors reported more eminent paracrine effects of hepatocytic AGE/RAGE stimulation (mediated by NOX4) with respect to the activation of HSCs and macrophages [62]

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"We built a single experimental peptide that works like four hormones at once, so we’re not pushing one button too hard." "Beyond helping with fullness and glucose control, GIP signaling has anti‑nausea effects — it can even block nausea in preclinical models, which is why we prioritize it in the mix," he went on