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The FDA has approved three GLP-1s in particular for both type 2 diabetes treatment and weight loss: Liraglutide (Saxenda, Victoza): While effective, this once-daily injection generally leads to more modest weight loss compared to newer options (it’s been around since 2014)

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249 ), liraglutide 250 and semaglutide 5 did not cross the blood–brain barrier but instead interacted with the brain through the circumventricular organs