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In support to this notion, RT-PCR studies demonstrated expression of both Epac2 and PLC-ε in STC-1 cells (data not shown) and a selective Epac ligand, 8-pCPT-2′- O -Me-cAMP (10 μM) stimulated PI hydrolysis that was significantly inhibited (75 ± 5% inhibition) by U73122 (1 μM) (Figure 3E)
