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Participants received once-weekly Wegovy injections or a placebo for 68 weeks while adopting healthy lifestyle changes, such as a nutritious diet and increased physical activity
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These findings indicate potential pathways through which incretin therapy may: Stimulate bone formation by activating osteoblasts Inhibit bone resorption via osteoclast suppression Influence calcium and phosphate homeostasis Together, these mechanisms offer biologic plausibility that GLPโ1 RAs could help preserve bone strength
