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When a small group of patients began taking a very tiny dose — starting at 0.0675 mg, compared to the label-recommended 0.25 mg — and increased it gradually, “they were able to tolerate it better than the folks who started the usual dose and tried to escalate it in the typical way,” says Alkhaddo

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“The mechanisms of how this happens is not fully known yet,” says Amit Zachariah, MD, a cardiologist with Duly based in Schaumburg, Illinois